Knowledge

BUSINESS CHALLENGES

• Dead Volume: 5 to 10 % of product loss per batch in formulation and filling area.
• Drainage Limitations: the filtration process configuration made line drainage impossible.
• Filtration Time: Average filtration cycle exceeded 2 hours on average per batch, limiting throughput volume.

SOLUTION

• Filter Sizing and Process Optimization
  We performed filter sizing study to decrease the throughput filtration time without compromise on quality.
• Downstream Vent Filtration
  We applied a vent filter downstream, enabling complete drainage of filling line and recovery of 98% of dead volume.
• Filter Media Selection and Validation
  Our lab scale trials identified the optimal Capsule with PES filter media and pore size, improving filtrate quality.

RESULT AND BENEFITS

• 50 % decrease in filtration time
• 98 % dead volume recovered
• Improved filtrate quality
• Faster and efficient batch

Download Success Story - Reducing Fitration Time and Recovery Dead Volumes